Analysis had been reviewed by the three-ways ANOVA that have pairwise evaluation accompanied by Tukey’s article hoc attempt

Analysis had been reviewed by the three-ways ANOVA that have pairwise evaluation accompanied by Tukey’s article hoc attempt


The primary goal of this study was to analyze urinary Na + , K + and the Na + :K + excretion ratio, for associations with changes in systolic blood pressure (SBP) in participants from the DASH–Sodium trial during the initial screening period in which participants were consuming their regular diet without dietary intervention. The secondary goals of this study were to investigate: (a) the impact of the salt sensitivity of blood pressure on these responses and (b) the impact of the DASH–Sodium dietary intervention, which lowers SBP and increases dietary K + intake, on these potential associations. Our analysis reports that in the DASH–Sodium study cohort: (1) a daily excretion of <1 g K + /day is associated with elevated SBP, (2) urinary K + excretion of >1 g/day does not correlate with a reduction in SBP and, (3) a reduction in the urinary Na + :K + excretion ratio is not associated with lower SBP irrespective of the salt sensitivity of blood pressure. Collectively our data support the recent DRI recommendation not to propose a DRI for K + and suggest that further evidence is required to support the establishment of a Na + /K + excretion ratio that would reduce SBP in the general population.

Analytical parameters

Mean SBP according to urinary salt to help you potassium (Na + /K + ) excretion proportion during the time of assessment and with weight reduction input away from Fat loss Approaches to End Blood pressure level (DASH) large sodium (HS) and you will lower salt (LS) diet plan into the (a) sodium sensitive and painful (n = 71), (b) salt unwilling (n = 119) people, viewpoints found since mean ± SD.

Significantly, we observed no association between the urinary Na + :K + ratio and SBP on the DASH HS or DASH LS dietary intervention in either SS (DASH HS R 2 = 0.04, DASH LS R 2 = 0.02) or SR (DASH HS R 2 = 0.04, DASH LS R 2 = 0.00002) participants (Fig. 5a, b). The DASH dietary intervention significantly increased the number of participants in both SS and SR groups with a urinary Na + :K + ratio of <1 on both the HS and LS diet. However, the urinary Na + :K + had no impact on SBP within dietary intake groups (Fig. 6a, b). Further, when expressed as a frequency distribution histogram the change in SBP from the DASH HS to LS dietary intervention exhibits a profound leftward shift in the SS group compared to SR group (Fig. 7a). In contrast, the frequency distribution histogram for change in the urinary Na + :K + ratio from the DASH HS to LS dietary intervention shows no difference in the Gaussian curve and distribution between SS and SR participants (Fig. 7b).

After that, numerous studies have advised that the blood pressure levels protection evoked by the K + intake may be determined by losing weight Na + intake [28, 29]. Inside our studies of Dashboard-Salt dataset i noticed zero relationship which have urinary K + removal and SBP, in diligent assessment check out or during Dash weight loss intervention whenever Na + intake are modified, indicating a liberty of one’s outcomes of Na + and you will K + with the SBP within this research. The latest 2019 DRI Declaration concluded that you will find shortage of proof towards the effects out of K + to the blood pressure and you can didn’t expose an effective DRI away from K + . The research support the 2019 DRI Declaration and you will means that losing weight K + supplements may not notably reduce hypertension on general populace.


Stamler J, Rose Grams, Stamler R, Elliott P, Dyer An excellent, Marmot Meters. INTERSALT research conclusions. Public health and medical care effects. Blood pressure levels. 1989;–eight.